The unique trimeric assembly of the virulence factor HtrA from <i>Helicobacter pylori</i> occurs via N-terminal domain swapping.

Zhang, Zhemin; Huang, Qi; Tao, Xuan; Song, Guobing; Zheng, Peng; Li, Hongyan; Sun, Hongzhe; Xia, Wei

The unique trimeric assembly of the virulence factor HtrA from Helicobacter pylori occurs via N-terminal domain swapping.

Zhang, Zhemin; Huang, Qi; Tao, Xuan; Song, Guobing; Zheng, Peng; Li, Hongyan; Sun, Hongzhe; Xia, Wei.

Afiliação

Zhang Z; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, China.
Huang Q; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, China.
Tao X; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, China.
Song G; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Zheng P; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Li H; Department of Chemistry, University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Sun H; Department of Chemistry, University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Xia W; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, China. Electronic address: xiawei5@mail.sysu.edu.cn.

J Biol Chem ; 294(20): 7990-8000, 2019 05 17.

Article em En | MEDLINE | ID: mdl-30936204

Assuntos

Proteínas de Bactérias/química; Helicobacter pylori/enzimologia; Modelos Biológicos; Serina Endopeptidases/química; Fatores de Virulência/química; Antígenos CD/química; Antígenos CD/genética; Antígenos CD/metabolismo; Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Caderinas/química; Caderinas/genética; Caderinas/metabolismo; Cristalografia por Raios X; Helicobacter pylori/genética; Helicobacter pylori/patogenicidade; Humanos; Domínios Proteicos; Serina Endopeptidases/genética; Serina Endopeptidases/metabolismo; Especificidade por Substrato; Fatores de Virulência/genética; Fatores de Virulência/metabolismo

Palavras-chave

Helicobacter pylori; PDZ domain; high-temperature requirement A (HtrA); protein structure; secretion; serine protease; virulence factor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Serina Endopeptidases / Helicobacter pylori / Fatores de Virulência / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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