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Expectation-induced modulation of metastable activity underlies faster coding of sensory stimuli.
Mazzucato, L; La Camera, G; Fontanini, A.
Afiliação
  • Mazzucato L; Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, NY, USA.
  • La Camera G; Departments of Biology and Mathematics and Institute of Neuroscience, University of Oregon, Eugene, OR, USA.
  • Fontanini A; Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, NY, USA. giancarlo.lacamera@stonybrook.edu.
Nat Neurosci ; 22(5): 787-796, 2019 05.
Article em En | MEDLINE | ID: mdl-30936557
Sensory stimuli can be recognized more rapidly when they are expected. This phenomenon depends on expectation affecting the cortical processing of sensory information. However, the mechanisms responsible for the effects of expectation on sensory circuits remain elusive. In the present study, we report a novel computational mechanism underlying the expectation-dependent acceleration of coding observed in the gustatory cortex of alert rats. We use a recurrent spiking network model with a clustered architecture capturing essential features of cortical activity, such as its intrinsically generated metastable dynamics. Relying on network theory and computer simulations, we propose that expectation exerts its function by modulating the intrinsically generated dynamics preceding taste delivery. Our model's predictions were confirmed in the experimental data, demonstrating how the modulation of ongoing activity can shape sensory coding. Altogether, these results provide a biologically plausible theory of expectation and ascribe an alternative functional role to intrinsically generated, metastable activity.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Cerebral / Sinais (Psicologia) / Percepção Gustatória / Antecipação Psicológica / Modelos Neurológicos / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Cerebral / Sinais (Psicologia) / Percepção Gustatória / Antecipação Psicológica / Modelos Neurológicos / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article