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Nomogram based on actual body weight for estimation of vancomycin maintenance dose in infants.
Pokorná, Pavla; Síma, Martin; Cerná, Olga; Slanar, Ondrej.
Afiliação
  • Pokorná P; a Institute of Pharmacology, First Faculty of Medicine , Charles University and General University Hospital in Prague , Prague , Czech Republic.
  • Síma M; b Department of Pediatrics and Adolescent Medicine (PICU/NICU), First Faculty of Medicine , Charles University and General University Hospital in Prague , Prague , Czech Republic.
  • Cerná O; c Intensive Care and Department of Pediatric Surgery , Erasmus MC - Sophia Childrens Hospital , Rotterdam , the Netherlands.
  • Slanar O; a Institute of Pharmacology, First Faculty of Medicine , Charles University and General University Hospital in Prague , Prague , Czech Republic.
Infect Dis (Lond) ; 51(5): 334-339, 2019 05.
Article em En | MEDLINE | ID: mdl-30950674
ABSTRACT

BACKGROUND:

Vancomycin is the first-choice antibiotic for infants with ß-lactam-resistant gram-positive bacterial infection. Despite long experience of prescribing of this drug optimal dosing is still challenging. This study aimed at investigating variables predicting vancomycin clearance in order to propose optimal maintenance dosing in infants treated for suspected or culture-proven sepsis.

METHODS:

Vancomycin pharmacokinetics was calculated in a one-compartmental model based on serum concentrations. A linear regression model was used to explore relationships between vancomycin clearance and expected covariates.

RESULTS:

Twenty-two patients were enrolled into the study. Median (IQR) postnatal age was 157 (112-238) days. The median (IQR) volume of distribution and clearance for vancomycin were 0.50 (0.39-0.94) L/kg and 0.112 (0.095-0.133) L/h/kg, respectively. Vancomycin clearance was associated with actual body weight, height, body surface area, gestational age, postnatal age, postmenstrual age and estimate glomerular filtration rate. Actual body weight was the best predictive variable for vancomycin clearance. Daily maintenance dose (mg) calculated as 76.28 × actual body weight (kg) - 41.57 most closely approximated optimal dosing based on individual pharmacokinetics. This relationship was used to construct a dosing nomogram.

CONCLUSIONS:

We developed an easy-to-use dosing nomogram for maintaining a vancomycin average steady-state concentration of 22.5 mg/L based on actual body weight.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peso Corporal / Vancomicina / Monitoramento de Medicamentos / Sepse / Nomogramas / Antibacterianos Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Female / Humans / Infant / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peso Corporal / Vancomicina / Monitoramento de Medicamentos / Sepse / Nomogramas / Antibacterianos Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Female / Humans / Infant / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article