Influence of gender, age, shelf-life, and conservation method on the biomechanical behavior of colon tissue under dynamic solicitation.
Clin Biomech (Bristol, Avon)
; 65: 34-40, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30954683
ABSTRACT
BACKGROUND:
Data from biomechanical tissue sample studies of the human digestive tract are highly variable. The aim of this study was to investigate 4 factors which could modify the mechanical response of human colonic specimens placed under dynamic solicitation until tissue rupture gender, age, shelf-life and conservation method.METHODS:
We performed uniaxial dynamic tests of human colonic specimens. Specimens were taken according to three different protocols refrigerated cadavers without embalming, embalmed cadavers and fresh colonic tissue. A total of 143 specimens were subjected to tensile tests, at a speed of 1â¯mâ¯s-1.FINDINGS:
Young's modulus of the different conservation protocols are as follows embalmed, 3.08⯱â¯1.99; fresh, 2.97⯱â¯2.59; and refrigerated 3.17⯱â¯2.05. The type of conservation does not modify the stiffness of the tissue (pâ¯=â¯0.26) but does modify the stress necessary for rupture (pâ¯<â¯0.001) and the strain required to obtain lesions of the outer layer and the inner layer (pâ¯<â¯0.001 and pâ¯<â¯0.05, respectively). Gender is also a factor responsible for a change in the mechanical response of the colon. The age of the subjects and the shelf-life of the bodies did not represent factors influencing the mechanical behavior of the colon (pâ¯>â¯0.05).INTERPRETATION:
The mechanical response of the colon tissue showed a biphasic injury process depending on gender and method of preservation. The age and shelf-life of anatomical subjects do not alter the mechanical response of the colon.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Preservação Biológica
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Colo
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Embalsamamento
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Módulo de Elasticidade
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article