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In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier.
Chlebek, Jakub; Korábecný, Jan; Dolezal, Rafael; Stepánková, Sárka; Pérez, Daniel I; Hostálková, Anna; Opletal, Lubomír; Cahlíková, Lucie; Macáková, Katerina; Kucera, Tomás; Hrabinová, Martina; Jun, Daniel.
Afiliação
  • Chlebek J; ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. jakub.chlebek@faf.cuni.cz.
  • Korábecný J; Biomedical Research Center, University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic. korabecny.jan1@gmail.com.
  • Dolezal R; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesská 1575, 500 01 Hradec Králové, Czech Republic. korabecny.jan1@gmail.com.
  • Stepánková S; Biomedical Research Center, University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic. rafael.dolezal@gmail.com.
  • Pérez DI; Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Králové, Rokitanského 62, 50003 Hradec Králové, Czech Republic. rafael.dolezal@gmail.com.
  • Hostálková A; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10 Pardubice, Czech Republic. Sarka.Stepankova@upce.cz.
  • Opletal L; Centro de Investigaciones Biológicas, Avenida Ramiro de Maetzu 9, 280 40 Madrid, Spain. dperez@cib.csic.es.
  • Cahlíková L; ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. HOSTA4AA@faf.cuni.cz.
  • Macáková K; ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. opletal@faf.cuni.cz.
  • Kucera T; ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. cahlikova@faf.cuni.cz.
  • Hrabinová M; ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. macakovak@faf.cuni.cz.
  • Jun D; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesská 1575, 500 01 Hradec Králové, Czech Republic. tomas.kucera2@unob.cz.
Molecules ; 24(7)2019 Apr 05.
Article em En | MEDLINE | ID: mdl-30959739
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Butirilcolinesterase / Inibidores da Colinesterase / Alcaloides Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Butirilcolinesterase / Inibidores da Colinesterase / Alcaloides Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article