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Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants.
Hattori, Shin-Ichiro; Hayashi, Hironori; Bulut, Haydar; Rao, Kalapala Venkateswara; Nyalapatla, Prasanth R; Hasegawa, Kazuya; Aoki, Manabu; Ghosh, Arun K; Mitsuya, Hiroaki.
Afiliação
  • Hattori SI; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
  • Hayashi H; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
  • Bulut H; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Rao KV; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.
  • Nyalapatla PR; Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana, USA.
  • Hasegawa K; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.
  • Aoki M; Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana, USA.
  • Ghosh AK; Protein Crystal Analysis Division, Japan Synchrotron Radiation Research Institute, Hyogo, Japan.
  • Mitsuya H; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
Antimicrob Agents Chemother ; 63(6)2019 06.
Article em En | MEDLINE | ID: mdl-30962341
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Protease de HIV / Antirreumáticos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Protease de HIV / Antirreumáticos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article