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Changes of clinical symptoms in patients with new psychoactive substance (NPS)-related disorders from fiscal year 2012 to 2014: A study in hospitals specializing in the treatment of addiction.
Funada, Daisuke; Matsumoto, Toshihiko; Tanibuchi, Yuko; Kawasoe, Yasunari; Sakakibara, Satoru; Naruse, Nobuya; Ikeda, Shunichiro; Sunami, Takashi; Muto, Takeo; Cho, Tetsuji.
Afiliação
  • Funada D; National Center of Neurology and Psychiatry, National Center Hospital, Kodaira, Japan.
  • Matsumoto T; National Center of Neurology and Psychiatry, National Institute of Mental Health, Kodaira, Japan.
  • Tanibuchi Y; National Center of Neurology and Psychiatry, National Institute of Mental Health, Kodaira, Japan.
  • Kawasoe Y; Chiba Hospital, Funabashi, Japan.
  • Sakakibara S; Asahi General Hospital, Asahi, Japan.
  • Naruse N; Tokyo Metropolitan Matsuzawa Hospital, Setagaya-ku, Japan.
  • Ikeda S; Saitama Psychiatric Medical Center, Inamachi, Japan.
  • Sunami T; Kansai Medical University, Hirakatashi, Japan.
  • Muto T; Okayama Psychiatric Medical Center, Kita-ku, Japan.
  • Cho T; Hizen Psychiatric Center, Kanzaki-gun, Japan.
Neuropsychopharmacol Rep ; 39(2): 119-129, 2019 06.
Article em En | MEDLINE | ID: mdl-30968601
AIMS: The use of new psychoactive substances (NPS) has become increasingly widespread over the last decade, in Japan and internationally. NPS are associated with a range of increasingly serious clinical, public, and social issues. Political measures to ameliorate the effects of NPS in Japan have focused on tightening regulation rather than establishing treatment methods. The current study sought to compare the neuropsychiatric symptoms of patients with NPS-related disorders across several years. We examined patients who attended specialized hospitals for treating addiction, to elucidate the impacts of legal measures to control NPS. METHODS: Subjects (n = 864) were patients with NPS-related disorders who received medical treatment at eight specialized hospitals for treating addiction in Japan between April 2012 and March 2015. Clinical information was collected retrospectively from medical records. RESULTS: Among psychiatric symptoms, the ratio of hallucinations/delusions decreased over time across 3 years of study (first year vs second year vs third year: 40.1% vs 30.9% vs 31.7%, P = 0.037). Among neurological symptoms, the ratio of coma/syncope increased over the 3-year period (7.8% vs 11.0% vs 17.0%, P = 0.002), as did the ratio of convulsions (2.8% vs 4.3% vs 9.7%, P = 0.001). CONCLUSION: The symptoms associated with NPS were primarily psychiatric in the first year, while the prevalence of neurological symptoms increased each year. The risk of death and the severity of symptoms were greater in the third year compared with the first year, as regulation of NPS increased.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Relacionados ao Uso de Substâncias / Hospitais Psiquiátricos Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Relacionados ao Uso de Substâncias / Hospitais Psiquiátricos Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2019 Tipo de documento: Article