Human TLR8 Senses RNA From <i>Plasmodium falciparum</i>-Infected Red Blood Cells Which Is Uniquely Required for the IFN-Î³ Response in NK Cells.

Coch, Christoph; Hommertgen, Benjamin; Zillinger, Thomas; Daßler-Plenker, Juliane; Putschli, Bastian; Nastaly, Maximilian; Kümmerer, Beate M; Scheunemann, Johanna F; Schumak, Beatrix; Specht, Sabine; Schlee, Martin; Barchet, Winfried; Hoerauf, Achim; Bartok, Eva; Hartmann, Gunther

Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-Î³ Response in NK Cells.

Coch, Christoph; Hommertgen, Benjamin; Zillinger, Thomas; Daßler-Plenker, Juliane; Putschli, Bastian; Nastaly, Maximilian; Kümmerer, Beate M; Scheunemann, Johanna F; Schumak, Beatrix; Specht, Sabine; Schlee, Martin; Barchet, Winfried; Hoerauf, Achim; Bartok, Eva; Hartmann, Gunther.

Afiliação

Coch C; Department of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Hommertgen B; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Bonn, Germany.
Zillinger T; Department of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Daßler-Plenker J; Department of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Putschli B; Department of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Nastaly M; Department of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Kümmerer BM; Department of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Scheunemann JF; Department of Virology, University Hospital Bonn, Bonn, Germany.
Schumak B; Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany.
Specht S; Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany.
Schlee M; Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany.
Barchet W; Department of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Hoerauf A; Department of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Bartok E; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Bonn, Germany.
Hartmann G; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Bonn, Germany.

Front Immunol ; 10: 371, 2019.

Article em En | MEDLINE | ID: mdl-30972055

Assuntos

Eritrócitos/parasitologia; Interferon gama/imunologia; Células Matadoras Naturais/imunologia; Malária Falciparum/imunologia; RNA de Protozoário/imunologia; Receptor 8 Toll-Like/imunologia; Animais; Linhagem Celular Tumoral; Modelos Animais de Doenças; Células HEK293; Humanos; Imunidade Inata/imunologia; Interleucina-12/imunologia; Interleucina-18/imunologia; Ativação Linfocitária/imunologia; Camundongos; Monócitos/imunologia; Plasmodium falciparum/imunologia; RNA de Protozoário/genética; Células THP-1; Receptor 7 Toll-Like/imunologia

Palavras-chave

NK cells; Plasmodium falciparum; innate immune system; interferon gamma; interleukin 12p70; interleukin 18; malaria; toll-like receptor 8

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / RNA de Protozoário / Interferon gama / Malária Falciparum / Eritrócitos / Receptor 8 Toll-Like Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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