Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation.
Stem Cell Res
; 37: 101431, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30974404
ABSTRACT
We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781â¯Gâ¯>â¯A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
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Síndrome de Romano-Ward
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Miócitos Cardíacos
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Canal de Potássio KCNQ1
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Células-Tronco Pluripotentes Induzidas
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Fibroblastos
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Mutação
Limite:
Adult
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Humans
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Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article