m<sup>6</sup>A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1.

Wu, Yingmin; Yang, Xiangling; Chen, Zhuojia; Tian, Lin; Jiang, Guanmin; Chen, Feng; Li, Jiexin; An, Panpan; Lu, Linlin; Luo, Nan; Du, Jun; Shan, Hong; Liu, Huanliang; Wang, Hongsheng

m⁶A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1.

Wu, Yingmin; Yang, Xiangling; Chen, Zhuojia; Tian, Lin; Jiang, Guanmin; Chen, Feng; Li, Jiexin; An, Panpan; Lu, Linlin; Luo, Nan; Du, Jun; Shan, Hong; Liu, Huanliang; Wang, Hongsheng.

Afiliação

Wu Y; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, and Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China.
Yang X; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, China.
Chen Z; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, China.
Tian L; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, Guangdong, China.
Jiang G; Department of Pharmacy, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, Guangdong, China.
Chen F; Department of Clinical Laboratory, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, Guangdong, China.
Li J; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, and Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China.
An P; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, and Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China.
Lu L; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, and Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China.
Luo N; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, and Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China.
Du J; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, and Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China.
Shan H; Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, and Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China.
Liu H; Key Laboratory of Biomedical Imaging of Guangdong Province, Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, Guangdong, China.
Wang H; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, China. liuhuanl@mail.sysu.edu.cn.

Mol Cancer ; 18(1): 87, 2019 04 13.

Article em En | MEDLINE | ID: mdl-30979372

Assuntos

Adenosina/análogos & derivados; Neoplasias Colorretais/genética; Regulação Neoplásica da Expressão Gênica; Neoplasias Hepáticas/genética; RNA Longo não Codificante/genética; Homeobox 1 de Ligação a E-box em Dedo de Zinco/genética; Adenosina/metabolismo; Animais; Sequência de Bases; Linhagem Celular Tumoral; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/mortalidade; Neoplasias Colorretais/patologia; Transição Epitelial-Mesenquimal; Proteínas F-Box/genética; Proteínas F-Box/metabolismo; Feminino; Ribonucleoproteínas Nucleares Heterogêneas Grupo A-B/genética; Ribonucleoproteínas Nucleares Heterogêneas Grupo A-B/metabolismo; Humanos; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/mortalidade; Neoplasias Hepáticas/secundário; Metástase Linfática; Masculino; Camundongos; Camundongos Nus; Estadiamento de Neoplasias; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Conformação de Ácido Nucleico; RNA Longo não Codificante/metabolismo; Transdução de Sinais; Análise de Sobrevida; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto; Homeobox 1 de Ligação a E-box em Dedo de Zinco/metabolismo

Palavras-chave

CRC; Cell dissemination; LncRNA RP11; Zeb1; hnRNPA2B1; m6A

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Regulação Neoplásica da Expressão Gênica / Adenosina / RNA Longo não Codificante / Homeobox 1 de Ligação a E-box em Dedo de Zinco / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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