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Effect of a honey and arginine-glutamine-hydroxymethylbutyrate mixture on the healing of colon anastomosis in rats immunosuppressed with tacrolimus.
Akbulut, S; Dogan, Z; Baskiran, A; Elbe, H; Turkoz, Y.
Afiliação
  • Akbulut S; Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine , Malatya , Turkey.
  • Dogan Z; Department of Anatomy, Adiyaman University Faculty of Medicine , Adiyaman , Turkey.
  • Baskiran A; Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine , Malatya , Turkey.
  • Elbe H; Department of Histology and Embryology, Sitki Kocman University Faculty of Medicine , Mugla , Turkey.
  • Turkoz Y; Department of Medical Biochemistry, Inonu University Faculty of Medicine , Malatya , Turkey.
Biotech Histochem ; 94(7): 514-521, 2019 Oct.
Article em En | MEDLINE | ID: mdl-30983411
We compared the effect of honey and a mixture of arginine-glutamine-hydroxymethylbutyrate (AGHMB) on healing of a descending colon anastomosis in rats that were immunosuppressed with tacrolimus (Tac). Sprague-Dawley rats were divided into four groups: untreated control, Tac, Tac + honey and Tac + AGHMB. Colon resection and anastomosis were performed on day 14 and re-laparotomy was performed on the day 21 of the study. Anastomotic bursting pressure, macroscopic adhesion score, weekly body weight changes, histopathological features and immunohistochemical staining of TGF-ß1 were determined for all groups. We found no significant difference in anastomotic bursting pressure among the experimental groups. We found significant weekly increases in body weight for the Tac + honey group. We found no significant difference in the weekly body weight measurements for the Tac + AGHMB group. We found significant increases in TGF-ß1 expression in the Tac + honey group compared to the control and Tac groups. No significant differences in inflammatory cell infiltration, fibroblast proliferation or collagen deposition were found between the Tac + honey and Tac + AGHMB groups; however, a significant difference in neovascularization between these groups was found. Neovascularization in the Tac + honey group was significantly greater than for the Tac + AGHMB group. We found that both honey and the AGHMB mixture were beneficial for anastomotic wound healing in rats that were immunosuppressed using Tac.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Cicatrização / Tacrolimo / Glutamina / Mel Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Cicatrização / Tacrolimo / Glutamina / Mel Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article