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Exploring the Antiangiogenic Potential of Solomonamide A Bioactive Precursors: In Vitro and in Vivo Evidences of the Inhibitory Activity of Solo F-OH During Angiogenesis.
Carrillo, Paloma; Martínez-Poveda, Beatriz; Cheng-Sánchez, Iván; Guerra, Jessica; Tobia, Chiara; López-Romero, J Manuel; Sarabia, Francisco; Medina, Miguel Ángel; Quesada, Ana R.
Afiliação
  • Carrillo P; Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Málaga, Andalucía Tech, 29071 Málaga, Spain. pcarrillo@uma.es.
  • Martínez-Poveda B; IBIMA (Biomedical Research Institute of Málaga), Málaga 29071, Spain. pcarrillo@uma.es.
  • Cheng-Sánchez I; Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Málaga, Andalucía Tech, 29071 Málaga, Spain. bmpoveda@uma.es.
  • Guerra J; IBIMA (Biomedical Research Institute of Málaga), Málaga 29071, Spain. bmpoveda@uma.es.
  • Tobia C; Department of Organic Chemistry, Faculty of Sciences, University of Málaga, Andalucía Tech, 29071 Málaga, Spain. medina@uma.es.
  • López-Romero JM; Department of Molecular and Translational Medicine, Experimental Oncology and Immunology, School of Medicine, University of Brescia, 25125 Brescia, Italy. j.guerra@unibs.it.
  • Sarabia F; Department of Molecular and Translational Medicine, Experimental Oncology and Immunology, School of Medicine, University of Brescia, 25125 Brescia, Italy. chiara.tobia@unibs.it.
  • Medina MÁ; Department of Organic Chemistry, Faculty of Sciences, University of Málaga, Andalucía Tech, 29071 Málaga, Spain. quesada@uma.es.
  • Quesada AR; Department of Organic Chemistry, Faculty of Sciences, University of Málaga, Andalucía Tech, 29071 Málaga, Spain. frsarabia@uma.es.
Mar Drugs ; 17(4)2019 Apr 15.
Article em En | MEDLINE | ID: mdl-30991727
Marine sponges are a prolific source of bioactive compounds. In this work, the putative antiangiogenic potential of a series of synthetic precursors of Solomonamide A, a cyclic peptide isolated from a marine sponge, was evaluated. By means of an in vitro screening, based on the inhibitory activity of endothelial tube formation, the compound Solo F-OH was selected for a deeper characterization of its antiangiogenic potential. Our results indicate that Solo F-OH is able to inhibit some key steps of the angiogenic process, including the proliferation, migration, and invasion of endothelial cells, as well as diminish their capability to degrade the extracellular matrix proteins. The antiangiogenic potential of Solo F-OH was confirmed by means of two different in vivo models: the chorioallantoic membrane (CAM) and the zebrafish yolk membrane (ZFYM) assays. The reduction in ERK1/2 and Akt phosphorylation in endothelial cells treated with Solo F-OH denotes that this compound could target the upstream components that are common to both pathways. Taken together, our results show a new and interesting biological activity of Solo F-OH as an inhibitor of the persistent and deregulated angiogenesis that characterizes cancer and other pathologies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Inibidores da Angiogênese Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Inibidores da Angiogênese Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article