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A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours.
Mak, Gabriel; Soria, Jean-Charles; Blagden, Sarah P; Plummer, Ruth; Fleming, Ronald A; Nebot, Noelia; Zhang, Jianping; Mazumdar, Jolly; Rogan, Debra; Gazzah, Anas; Rizzuto, Ivana; Greystoke, Alastair; Yan, Li; Tolson, Jerry; Auger, Kurt R; Arkenau, Hendrik-Tobias.
Afiliação
  • Mak G; Sarah Cannon Research Institute, London, UK.
  • Soria JC; Cancer Centre, University College London, London, UK.
  • Blagden SP; Drug Development Department at Gustave Roussy Cancer Campus, University Paris-Sud, Paris, France.
  • Plummer R; Department of Oncology, Imperial College Healthcare NHS Trust, London, UK.
  • Fleming RA; Department of Oncology, University of Oxford, Oxford, UK.
  • Nebot N; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
  • Zhang J; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, PA, USA.
  • Mazumdar J; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, PA, USA.
  • Rogan D; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.
  • Gazzah A; PAREXEL International, Durham, NC, USA.
  • Rizzuto I; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, PA, USA.
  • Greystoke A; Chimeron Bio, New York, NY, 10016, USA.
  • Yan L; GlaxoSmithKline, Research Triangle Park, NC and Upper Providence, Collegeville, PA, USA.
  • Tolson J; Drug Development Department at Gustave Roussy Cancer Campus, University Paris-Sud, Paris, France.
  • Auger KR; Department of Oncology, Imperial College Healthcare NHS Trust, London, UK.
  • Arkenau HT; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Br J Cancer ; 120(10): 975-981, 2019 05.
Article em En | MEDLINE | ID: mdl-30992546
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Pirimidinonas / Proteína-Tirosina Quinases de Adesão Focal / Aminopiridinas / Ácidos Hidroxâmicos / Neoplasias Tipo de estudo: Diagnostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Pirimidinonas / Proteína-Tirosina Quinases de Adesão Focal / Aminopiridinas / Ácidos Hidroxâmicos / Neoplasias Tipo de estudo: Diagnostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article