Demystifying a hexuronic acid ligand that recognizes Toxoplasma gondii and blocks its invasion into host cells.
Org Biomol Chem
; 17(18): 4535-4542, 2019 05 08.
Article
em En
| MEDLINE
| ID: mdl-30994681
ABSTRACT
Toxoplasma gondii is a ubiquitous eukaryotic pathogen responsible for toxoplasmosis in humans and animals. This parasite is an obligate intracellular pathogen and actively invades susceptible host cells, a process which is mediated by specific receptor-ligand interactions. Here, we have identified an unnatural 2,4-disulfated d-glucuronic acid (Di-S-GlcA), a hexuronic acid composed of heparin/heparan sulfate, as a potential carbohydrate ligand that can selectively bind to T. gondii parasites. More importantly, the gelatin conjugated Di-S-GlcA multivalent probe displayed strong inhibition of parasite entry into host cells. These results open perspective for the future use of Di-S-GlcA epitopes in biomedical applications against toxoplasmosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxoplasma
/
Glucuronatos
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article