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Application of Acyzol in the Context of Zinc Deficiency and Perspectives.
Aliev, Gjumrakch; Li, Yi; Chubarev, Vladimir N; Lebedeva, Svetlana A; Parshina, Lidiya N; Trofimov, Boris A; Sologova, Susanna S; Makhmutova, Alfiya; Avila-Rodriguez, Marco F; Klochkov, Sergey G; Galenko-Yaroshevsky, Pavel A; Tarasov, Vadim V.
Afiliação
  • Aliev G; Department of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia. aliev03@gmail.com.
  • Li Y; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka 142432, Russia. aliev03@gmail.com.
  • Chubarev VN; GALLY International Research Institute, 7733 Louis Pasteur Drive #330, San Antonio, TX 78229, USA. aliev03@gmail.com.
  • Lebedeva SA; Department of Biological and Health Sciences, Texas A&M University-Kingsville, TX 78363, USA. yi.li@tamuk.edu.
  • Parshina LN; Department of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia. tchoubarov@mail.ru.
  • Trofimov BA; Department of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia. lebedeva502@yandex.ru.
  • Sologova SS; A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia. parshina@irioch.irk.ru.
  • Makhmutova A; A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia. boris_trofimov@irioch.irk.ru.
  • Avila-Rodriguez MF; Department of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia. susanna.sologova@yandex.ru.
  • Klochkov SG; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka 142432, Russia. alfiya@ipac.ac.ru.
  • Galenko-Yaroshevsky PA; Universidad del Tolima, Facultad de Ciencias de la Salud, Barrio Santa Helena, Ibagué 730006, Colombia. markos.avila@gmail.com.
  • Tarasov VV; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka 142432, Russia. klochkov@ipac.ac.ru.
Int J Mol Sci ; 20(9)2019 Apr 29.
Article em En | MEDLINE | ID: mdl-31035445
Zinc is one of the most important essential trace elements. It is involved in more than 300 enzyme systems and is an indispensable participant in many biochemical processes. Zinc deficiency causes a number of disorders in the human body, the main ones being the delay of growth and puberty, immune disorders, and cognitive dysfunctions. There are over two billion people in the world suffering from zinc deficiency conditions. Acyzol, a zinc-containing medicine, developed as an antidote against carbon monoxide poisoning, demonstrates a wide range of pharmacological activities: Anti-inflammatory, reparative, detoxifying, immunomodulatory, bacteriostatic, hepatoprotective, adaptogenic, antioxidant, antihypoxic, and cardioprotective. The presence of zinc in the composition of Acyzol suggests the potential of the drug in the treatment and prevention of zinc deficiency conditions, such as Prasad's disease, immune system pathology, alopecia, allergodermatoses, prostate dysfunction, psoriasis, stomatitis, periodontitis, and delayed mental and physical development in children. Currently, the efficiency of Acyzol in the cases of zinc deficiency is shown in a large number of experimental studies. So, Acyzol can be used as a highly effective drug for pharmacologic therapy of a wide range of diseases and conditions and it opens up new perspectives in the treatment and prevention of zinc deficiency conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligoelementos / Zinco / Acetato de Zinco / Distúrbios Nutricionais Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligoelementos / Zinco / Acetato de Zinco / Distúrbios Nutricionais Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article