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In Vivo Pharmacodynamics of Omadacycline against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model.
Lepak, Alexander J; Zhao, Miao; Marchillo, Karen; VanHecker, Jamie; Andes, David R.
Afiliação
  • Lepak AJ; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Zhao M; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Marchillo K; William S. Middleton Memorial VA Hospital, Madison, Wisconsin, USA.
  • VanHecker J; William S. Middleton Memorial VA Hospital, Madison, Wisconsin, USA.
  • Andes DR; William S. Middleton Memorial VA Hospital, Madison, Wisconsin, USA.
Antimicrob Agents Chemother ; 63(7)2019 07.
Article em En | MEDLINE | ID: mdl-31036691
Omadacycline is a novel aminomethylcycline antibiotic with potent activity against Staphylococcus aureus, including methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). We investigated the pharmacodynamic activity of omadacycline against 10 MSSA/MRSA strains in a neutropenic murine thigh model. The median 24-h area under the concentration-time curve (AUC)/MIC values associated with net stasis and 1-log kill were 21.9 and 57.7, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Tetraciclinas / Coxa da Perna / Staphylococcus aureus Resistente à Meticilina / Neutropenia Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Tetraciclinas / Coxa da Perna / Staphylococcus aureus Resistente à Meticilina / Neutropenia Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article