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Isolation and characterisation of goat C-reactive protein.
Biochim Biophys Acta ; 924(1): 75-80, 1987 Apr 16.
Article em En | MEDLINE | ID: mdl-3103696
A pentraxin was isolated from acute phase goat serum by its calcium-dependent affinity for agarose, and although it did not bind to phosphorylcholine immobilised on Sepharose, its binding to agarose was reversed by exposure to fluid phase phosphorylcholine. It was identified as goat C-reactive protein on the basis of its immunochemical cross-reactivity with human and bovine C-reactive protein. The molecule was composed of five identical, glycosylated, non-covalently associated subunits, each of molecular weight approx. 24,000. Acute phase serum levels in a small number of samples were not significantly different from normal levels (means 72 and 55 micrograms/ml, respectively), suggesting that goat C-reactive protein is not a major acute phase reactant. No other pentraxin was detected in goat serum.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa Limite: Animals Idioma: En Ano de publicação: 1987 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa Limite: Animals Idioma: En Ano de publicação: 1987 Tipo de documento: Article