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Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.
Klotz, Luisa; Eschborn, Melanie; Lindner, Maren; Liebmann, Marie; Herold, Martin; Janoschka, Claudia; Torres Garrido, Belén; Schulte-Mecklenbeck, Andreas; Gross, Catharina C; Breuer, Johanna; Hundehege, Petra; Posevitz, Vilmos; Pignolet, Béatrice; Nebel, Giulia; Glander, Shirin; Freise, Nicole; Austermann, Judith; Wirth, Timo; Campbell, Graham R; Schneider-Hohendorf, Tilman; Eveslage, Maria; Brassat, David; Schwab, Nicholas; Loser, Karin; Roth, Johannes; Busch, Karin B; Stoll, Monika; Mahad, Don J; Meuth, Sven G; Turner, Timothy; Bar-Or, Amit; Wiendl, Heinz.
Afiliação
  • Klotz L; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany. luisa.klotz@ukmuenster.de.
  • Eschborn M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Lindner M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Liebmann M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Herold M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Janoschka C; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Torres Garrido B; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Schulte-Mecklenbeck A; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Gross CC; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Breuer J; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Hundehege P; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Posevitz V; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Pignolet B; CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France.
  • Nebel G; University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany.
  • Glander S; University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany.
  • Freise N; University of Münster, Department of Immunology, 48149 Münster, Germany.
  • Austermann J; University of Münster, Department of Immunology, 48149 Münster, Germany.
  • Wirth T; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Campbell GR; University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK.
  • Schneider-Hohendorf T; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Eveslage M; University of Münster, Institute of Biostatistics and Clinical Research, 48149 Münster, Germany.
  • Brassat D; CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France.
  • Schwab N; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Loser K; University Hospital Münster, Department of Dermatology, 48149 Münster, Germany.
  • Roth J; University of Münster, Department of Immunology, 48149 Münster, Germany.
  • Busch KB; University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany.
  • Stoll M; University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany.
  • Mahad DJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 ER Maastricht, Netherlands.
  • Meuth SG; University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK.
  • Turner T; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
  • Bar-Or A; Sanofi Genzyme, Cambridge, MA 02142, USA.
  • Wiendl H; Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sci Transl Med ; 11(490)2019 05 01.
Article em En | MEDLINE | ID: mdl-31043571

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toluidinas / Crotonatos / Linfócitos T / Mitocôndrias / Esclerose Múltipla Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toluidinas / Crotonatos / Linfócitos T / Mitocôndrias / Esclerose Múltipla Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article