The mitochondrial R-loop.
Nucleic Acids Res
; 47(11): 5480-5489, 2019 06 20.
Article
em En
| MEDLINE
| ID: mdl-31045202
ABSTRACT
The DNA in mitochondria contributes essential components of the organelle's energy producing machinery that is essential for life. In 1971, many mitochondrial DNA molecules were found to have a third strand of DNA that maps to a region containing critical regulatory elements for transcription and replication. Forty-five years later, a third strand of RNA in the same region has been reported. This mitochondrial R-loop is present on thousands of copies of mitochondrial DNA per cell making it potentially the most abundant R-loop in nature. Here, I assess the discovery of the mitochondrial R-loop, discuss why it remained unrecognized for almost half a century and propose for it central roles in the replication, organization and expression of mitochondrial DNA, which if compromised can lead to disease states.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Mitocondrial
/
RNA
/
Replicação do DNA
/
Mitocôndrias
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article