Cellular functions of long noncoding RNAs.

Yao, Run-Wen; Wang, Yang; Chen, Ling-Ling

Yao, Run-Wen; Wang, Yang; Chen, Ling-Ling.

Afiliação

Yao RW; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Wang Y; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Chen LL; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. linglingchen@s

Nat Cell Biol ; 21(5): 542-551, 2019 05.

Article em En | MEDLINE | ID: mdl-31048766

ABSTRACT

ABSTRACT

A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in gene expression networks by controlling nuclear architecture and transcription in the nucleus and by modulating mRNA stability, translation and post-translational modifications in the cytoplasm. In this Review, we highlight recent progress in cellular functions of lncRNAs at the molecular level in mammalian cells.

Assuntos

Fenômenos Fisiológicos Celulares/genética; Genoma/genética; Biossíntese de Proteínas/genética; RNA Longo não Codificante/genética; Animais; Redes Reguladoras de Genes/genética; Humanos; Processamento de Proteína Pós-Traducional/genética; Estabilidade de RNA/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biossíntese de Proteínas / Fenômenos Fisiológicos Celulares / Genoma / RNA Longo não Codificante Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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