Sesquiterpenes from an Endophytic Aspergillus flavus.
J Nat Prod
; 82(5): 1063-1071, 2019 05 24.
Article
em En
| MEDLINE
| ID: mdl-31050424
ABSTRACT
Eight new cadinene-sesquiterpenes (1-8), one eudesmane-sesquiterpene (9), and three known compounds (10-13) were isolated from an endophytic fungus, Aspergillus flavus, which was isolated from a toxic medicinal plant, Tylophora ovata. Their structures were elucidated by interpretation of spectroscopic data, and absolute configurations determined according to the specific rotation and electron circular dichroism methods. Compounds 4-8, 11, and 12 exhibited latent hepatic protection effects at 10 µM, and compound 12 selectively inhibited the proliferation of MCF-7 breast cancer cells with an IC50 values of 2.6 µM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aspergillus flavus
/
Sesquiterpenos
/
Endófitos
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article