Magmenthanes A-H: Eight new meroterpenoids from the bark of Magnolia officinalis var. Biloba.
Bioorg Chem
; 88: 102948, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31054429
ABSTRACT
Eight new meroterpenoids with different types of monoterpene units, namely, magmenthanes A-H (1-8), were identified from the bark of Magnolia officinalis var. biloba. Magmenthane A (1) possesses a 1,3-dioxabicyclo [4.3.01,5] nonane skeleton, 1-5 possess five pairs of enantiomers and 6 possesses a 1,1'-diallyl-biphenyl fragment. The structures of 1-8 were elucidated on the basis of 1D and 2D NMR, HRESIMS and electronic circular dichroism (ECD) calculations. Compounds 5 and 8 displayed significant PTP1B inhibitory activities with IC50 values of 4.38 and 3.88⯵M, respectively.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terpenos
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Extratos Vegetais
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Fármacos Neuroprotetores
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Casca de Planta
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Magnolia
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Inibidores Enzimáticos
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Proteína Tirosina Fosfatase não Receptora Tipo 1
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article