Sonic hedgehog (Shh) and CC chemokine ligand 2 signaling pathways in asthma.
J Chin Med Assoc
; 82(5): 343-350, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-31058710
ABSTRACT
Asthma is a chronic inflammatory disease of the airways in which many cells are involved, including mast cells, eosinophils, T lymphocytes, and so on. During the process, many chemokines and mediators are released to engage in recruiting and activating eosinophils and other inflammatory cells. Also, some signaling pathways are involved in the pathobiology of asthma. Sonic hedgehog (Shh) is one of the members of hedgehog gene families. Shh signaling plays a critical role in the embryonic development, including the lung. Previous findings from our team reveal that Shh is involved in the asthma pathogenesis. Recombinant Shh could induce the CC chemokine ligand 2 (CCL2) overexpressing and Smo inhibitor GDC-O449 could inhibit CCL2 expression in airway epithelial cells, monocytes, or macrophages. Hence, we reviewed the effects of Shh and CCL2 signaling pathways, and the interaction between signaling pathways in asthma.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Quimiocina CCL2
/
Proteínas Hedgehog
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article