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Screening of the pathogen box for the identification of anti-Acanthamoeba agents.
Sifaoui, Ines; Reyes-Batlle, María; López-Arencibia, Atteneri; Chiboub, Olfa; Bethencourt-Estrella, Carlos J; San Nicolás-Hernández, Desirée; Rodríguez Expósito, Rubén L; Rizo-Liendo, Aitor; Piñero, José E; Lorenzo-Morales, Jacob.
Afiliação
  • Sifaoui I; University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain; Laboratoire Matériaux-Molécules et Applications, IPEST, B.P 51 2070, La Marsa, University of Carthage, Tunisia.
  • Reyes-Batlle M; University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.
  • López-Arencibia A; University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.
  • Chiboub O; University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain; Laboratoire Matériaux-Molécules et Applications, IPEST, B.P 51 2070, La Marsa, University of Carthage, Tunisia.
  • Bethencourt-Estrella CJ; University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.
  • San Nicolás-Hernández D; University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.
  • Rodríguez Expósito RL; University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.
  • Rizo-Liendo A; University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.
  • Piñero JE; University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain. Electronic address: jpinero@ull.edu.es.
  • Lorenzo-Morales J; University Institute of Tropical Diseases and Public Health, Universidad de La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271, la Laguna Tenerife, Canary Islands, Spain.
Exp Parasitol ; 201: 90-92, 2019 Jun.
Article em En | MEDLINE | ID: mdl-31059693
ABSTRACT
Acanthamoeba are free living amoeba that have been isolated from different environments like soil, water, air dust. Moreover, they are also able to act as opportunist pathogens, mainly causing a fatal encephalitis and also keratitis in both human and animals. This study was aimed to evaluate the activity of the Medicines for Malaria Venture (MMV) compounds against the trophozoite stage of Acanthamoeba castellanii Neff. Sixteen compounds showed ≥90% inhibition of parasite growth in the initial screen (10 µM). Those set were further evaluated to determine the inhibitor concentration that inhibit the 50% of the initial population and cytotoxicity against murine macrophages. Among the compounds included in the pathogen box, pentamidine and posaconazole were the most effective against this parasite with an of IC50 of 0.567 ±â€¯0.04 and 0.630 ±â€¯0.11, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acanthamoeba castellanii / Amebicidas Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acanthamoeba castellanii / Amebicidas Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article