Derivation of biomonitoring equivalents (BE values) for zinc.
Regul Toxicol Pharmacol
; 106: 178-186, 2019 Aug.
Article
em En
| MEDLINE
| ID: mdl-31063796
ABSTRACT
Zinc is an essential nutrient in which deficiency or excess exposure can result in adverse health effects. Several organizations have established exposure guidance values to protect against deficiency and toxicity. Population-level biomonitoring data for zinc in whole blood, serum and urine are available from the Canadian Health Measures Survey (CHMS) and the US National Health and Nutrition Examination Survey (NHANES). This paper derived Biomonitoring Equivalent values (BEs) for zinc. BEs are tools based upon exposure guidance values to interpret biomonitoring data in the context of potential health risks. A regression between intake and serum/plasma concentration was derived to generate BEs for serum/plasma and whole blood. BEs for urine were derived using mass balance approach with a urine excretion fraction of 0.04. The BE values for deficiency ranged from 860 to 866, 6017-6059 and 159-206⯵g/L for serum/plasma, whole blood and urine, respectively. BEs to protect against toxicity for serum/plasma, whole blood, and urine were in the range of 895-1281, 6265-8969 and 439-3489⯵g/L, respectively. When interpreting biomonitoring data in a health-risk context, urinary zinc may be a more reliable biomarker of exposure than blood due to homeostasis in blood.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zinco
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Exposição Ambiental
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Monitoramento Biológico
Tipo de estudo:
Etiology_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article