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Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response.
Baeuerle, Patrick A; Ding, Jian; Patel, Ekta; Thorausch, Niko; Horton, Holly; Gierut, Jessica; Scarfo, Irene; Choudhary, Rashmi; Kiner, Olga; Krishnamurthy, Janani; Le, Bonnie; Morath, Anna; Baldeviano, G Christian; Quinn, Justin; Tavares, Patrick; Wei, Qi; Weiler, Solly; Maus, Marcela V; Getts, Daniel; Schamel, Wolfgang W; Hofmeister, Robert.
Afiliação
  • Baeuerle PA; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Ding J; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Patel E; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Thorausch N; Department of Immunology, Faculty of Biology, BIOSS Center for Biological Signalling Studies, CIBSS-Centre for Integrative Biological Signalling Studies and Centre for Chronic Immunodeficiency CCI, University of Freiburg, Schänzlestraße 18, Freiburg, 79104, Germany.
  • Horton H; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Gierut J; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Scarfo I; Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center and Harvard Medical School, Bldg. 149 13th Street, Charlestown, MA, USA.
  • Choudhary R; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Kiner O; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Krishnamurthy J; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Le B; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Morath A; Department of Immunology, Faculty of Biology, BIOSS Center for Biological Signalling Studies, CIBSS-Centre for Integrative Biological Signalling Studies and Centre for Chronic Immunodeficiency CCI, University of Freiburg, Schänzlestraße 18, Freiburg, 79104, Germany.
  • Baldeviano GC; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Quinn J; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Tavares P; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Wei Q; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Weiler S; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Maus MV; Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center and Harvard Medical School, Bldg. 149 13th Street, Charlestown, MA, USA.
  • Getts D; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA.
  • Schamel WW; Department of Immunology, Faculty of Biology, BIOSS Center for Biological Signalling Studies, CIBSS-Centre for Integrative Biological Signalling Studies and Centre for Chronic Immunodeficiency CCI, University of Freiburg, Schänzlestraße 18, Freiburg, 79104, Germany.
  • Hofmeister R; TCR² Therapeutics, Inc., 100 Binney Street, Cambridge, MA, 02142, USA. robert@tcr2.com.
Nat Commun ; 10(1): 2087, 2019 05 07.
Article em En | MEDLINE | ID: mdl-31064990
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos T / Linfócitos T / Imunoterapia Adotiva / Anticorpos de Cadeia Única / Receptores Artificiais / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos T / Linfócitos T / Imunoterapia Adotiva / Anticorpos de Cadeia Única / Receptores Artificiais / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article