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Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.
Bryan, Marian C; Drobnick, Joy; Gobbi, Alberto; Kolesnikov, Aleksandr; Chen, Yongsheng; Rajapaksa, Naomi; Ndubaku, Chudi; Feng, Jianwen; Chang, Willy; Francis, Ross; Yu, Christine; Choo, Edna F; DeMent, Kevin; Ran, Yingqing; An, Le; Emson, Claire; Huang, Zhiyu; Sujatha-Bhaskar, Swathi; Brightbill, Hans; DiPasquale, Antonio; Maher, Jonathan; Wai, John; McKenzie, Brent S; Lupardus, Patrick J; Zarrin, Ali A; Kiefer, James R.
Afiliação
  • Bryan MC; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Drobnick J; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Gobbi A; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Kolesnikov A; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Chen Y; WuXi Apptec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone , Shanghai 200131 , P. R. China.
  • Rajapaksa N; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Ndubaku C; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Feng J; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Chang W; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Francis R; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Yu C; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Choo EF; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • DeMent K; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Ran Y; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • An L; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Emson C; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Huang Z; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Sujatha-Bhaskar S; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Brightbill H; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • DiPasquale A; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Maher J; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Wai J; WuXi Apptec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone , Shanghai 200131 , P. R. China.
  • McKenzie BS; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Lupardus PJ; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Zarrin AA; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
  • Kiefer JR; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
J Med Chem ; 62(13): 6223-6240, 2019 07 11.
Article em En | MEDLINE | ID: mdl-31082230
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Inibidores de Proteínas Quinases / Quinases Associadas a Receptores de Interleucina-1 Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Inibidores de Proteínas Quinases / Quinases Associadas a Receptores de Interleucina-1 Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article