Your browser doesn't support javascript.
loading
Pomegranate juice and extract extended lifespan and reduced intestinal fat deposition in Caenorhabditis elegans.
Zheng, Jolene; Heber, David; Wang, Mingming; Gao, Chenfei; Heymsfield, Steven B; Martin, Roy J; Greenway, Frank L; Finley, John W; Burton, Jeffrey H; Johnson, William D; Enright, Frederick M; Keenan, Michael J; Li, Zhaoping.
Afiliação
  • Zheng J; 1 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
  • Heber D; 2 School of Nutrition and Food Sciences, Louisiana State University, Baton Rouge, LA, USA.
  • Wang M; 3 Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Gao C; 2 School of Nutrition and Food Sciences, Louisiana State University, Baton Rouge, LA, USA.
  • Heymsfield SB; 2 School of Nutrition and Food Sciences, Louisiana State University, Baton Rouge, LA, USA.
  • Martin RJ; 1 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
  • Greenway FL; 4 Department of Nutrition, University of California, Davis, CA, USA.
  • Finley JW; 1 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
  • Burton JH; 2 School of Nutrition and Food Sciences, Louisiana State University, Baton Rouge, LA, USA.
  • Johnson WD; 1 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
  • Enright FM; 1 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
  • Keenan MJ; 5 School of Animal Sciences, Louisiana State University, Baton Rouge, LA, USA.
  • Li Z; 1 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Int J Vitam Nutr Res ; 87(3-4): 149-158, 2017 May.
Article em En | MEDLINE | ID: mdl-31084484
Pomegranate juice with a high content of polyphenols, pomegranate extract, ellagic acid, and urolithin A, have anti-oxidant and anti-obesity effects in humans. Pomegranate juice extends lifespan of Drosophila melanogaster. Caenorhabditis elegans (C. elegans) (n = 6) compared to the control group in each treatment, lifespan was increased by pomegranate juice in wild type (N2, 56 %, P < 0.001) and daf-16 mutant (daf-16(mgDf50)I) (18 %, P = 0.00012), by pomegranate extract in N2 (28 %, P = 0.00004) and in daf-16(mgDf50)I (10 %, P < 0.05), or by ellagic acid (11 %, P < 0.05). Pomegranate juice reduced intestinal fat deposition (IFD) in C. elegans (n = 10) N2 (-68 %, P = 0.0003) or in the daf-16(mgDf50)I (-33 %, P = 0.0034). The intestinal fat deposition was increased by pomegranate extract in N2 (137 %, P < 0.0138) and in daf-16(mgDf50)I (26 %, P = 0.0225), by ellagic acid in N2 (66 %, P < 0.0001) and in daf-16(mgDf50)I (74 %, P < 0.0001), or by urolithin A in N2 (57 %, P = 0.0039) and in daf-16(mgDf50)I (43 %, P = 0.0001). These effects were partially mediated by the daf-16 pathway. The data may offer insights to human aging and obesity due to homology with C. elegans.
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article