Definition and quantification of six immune- and neuroregulatory serum proteins in healthy and demented elderly.
Neurodegener Dis Manag
; 9(4): 193-203, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31099300
ABSTRACT
Aim:
Blood-based biomarkers related to immune- and neuroregulatory processes may be indicative of dementia but lack standardization and proof-of-principle studies. Materials &methods:
The blood serum collection protocol as well as the analytic procedure to quantify the markers BDNF, IGF-1, VEGF, TGF-ß 1, MCP-1 and IL-18 in blood serum were standardized and their concentrations were compared between groups of 81 Alzheimer's disease patients and 79 healthy controls.Results:
Applying standardized methods, results for the quantification of the six markers in blood serum are stable and their concentrations significantly differ for all analytes except VEGF between patients diagnosed with Alzheimer's disease and healthy controls.Conclusion:
Analyzing a panel of six markers in blood serum under standardized conditions may serve as a diagnostic tool in primary dementia care in the future.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Insulin-Like I
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Quimiocina CCL2
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Fator Neurotrófico Derivado do Encéfalo
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Interleucina-18
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Fator A de Crescimento do Endotélio Vascular
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Fator de Crescimento Transformador beta1
/
Doença de Alzheimer
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
/
Guideline
/
Prognostic_studies
Limite:
Aged
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Aged80
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article