"Breathing" Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design.

Wu, Yan; Gao, George F

Wu, Yan; Gao, George F.

Afiliação

Wu Y; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences (CAS), 100101 Beijing, China.
Gao GF; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences (CAS), 100101 Beijing, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, China. Electronic address: gaof@im.ac.cn.

Cell ; 177(5): 1086-1088, 2019 05 16.

Article em En | MEDLINE | ID: mdl-31100263

ABSTRACT

ABSTRACT

A universal vaccine against influenza remains a critical target, and efforts have recently focused on the stem of the hemagglutinin glycoprotein. In this issue of Cell and a related Cell Host & Microbe article, three studies identify broad protective epitopes in the hemagglutinin head domain that are exposed by trimer "breathing."

Assuntos

Vacinas contra Influenza; Influenza Humana; Anticorpos Neutralizantes; Anticorpos Antivirais; Epitopos; Glicoproteínas de Hemaglutininação de Vírus da Influenza; Hemaglutininas; Humanos; Imunoglobulina G

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Influenza Humana Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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