Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition.
Bioorg Med Chem Lett
; 29(14): 1746-1748, 2019 07 15.
Article
em En
| MEDLINE
| ID: mdl-31103445
ABSTRACT
Structure based virtual screening attempts to discover DUSP1 inhibitors have yielded a scaffold featuring benzoxazole and acylthiourea pharmacophore. A series of its analogues were synthesized to explore structure activity relationship (SAR) of DUSP1 inhibition.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatase 1 de Especificidade Dupla
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article