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Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition.
Yeon Kim, Bo; Hee Yoon, Ji; Kim, Myeongbin; Nyoung Kim, Jae; Park, Hwangseo; Eon Ryu, Seong; Lee, Sangku.
Afiliação
  • Yeon Kim B; Anticancer Agent Research Center, KRIBB, Cheongju 28116, Republic of Korea.
  • Hee Yoon J; Anticancer Agent Research Center, KRIBB, Cheongju 28116, Republic of Korea.
  • Kim M; Department of Bioengineering, Hanyang University, Seoul 04763, Republic of Korea.
  • Nyoung Kim J; Department of Chemistry, Chonnam National University, Gwangju 61186, Republic of Korea.
  • Park H; Department of Bioscience and Biotechnology, Sejong University, Seoul 05006, Republic of Korea.
  • Eon Ryu S; Department of Bioengineering, Hanyang University, Seoul 04763, Republic of Korea. Electronic address: ryuse@hanyang.ac.kr.
  • Lee S; Anticancer Agent Research Center, KRIBB, Cheongju 28116, Republic of Korea. Electronic address: sangku@kribb.re.kr.
Bioorg Med Chem Lett ; 29(14): 1746-1748, 2019 07 15.
Article em En | MEDLINE | ID: mdl-31103445
ABSTRACT
Structure based virtual screening attempts to discover DUSP1 inhibitors have yielded a scaffold featuring benzoxazole and acylthiourea pharmacophore. A series of its analogues were synthesized to explore structure activity relationship (SAR) of DUSP1 inhibition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatase 1 de Especificidade Dupla Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatase 1 de Especificidade Dupla Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article