Minimizing threat via heuristic and optimal policies recruits hippocampus and medial prefrontal cortex.
Nat Hum Behav
; 3(7): 733-745, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31110338
ABSTRACT
Jointly minimizing multiple threats over extended time horizons enhances survival. Consequently, many tests of approach-avoidance conflicts incorporate multiple threats for probing corollaries of animal and human anxiety. To facilitate computations necessary for threat minimization, the human brain may concurrently harness multiple decision policies and associated neural controllers, but it is unclear which. We combine a task that mimics foraging under predation with behavioural modelling and functional neuroimaging. Human choices rely on immediate predator probability-a myopic heuristic policy-and on the optimal policy, which integrates all relevant variables. Predator probability relates positively and the associated choice uncertainty relates negatively to activations in the anterior hippocampus, amygdala and dorsolateral prefrontal cortex. The optimal policy is positively associated with dorsomedial prefrontal cortex activity. We thus provide a decision-theoretic outlook on the role of the human hippocampus, amygdala and prefrontal cortex in resolving approach-avoidance conflicts relevant for anxiety and integral for survival.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ansiedade
/
Aprendizagem da Esquiva
/
Comportamento de Escolha
/
Córtex Pré-Frontal
/
Tomada de Decisões
/
Hipocampo
/
Tonsila do Cerebelo
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
/
Humans
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Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article