Significance of baseline computed tomography assessment for predicting the pulmonary fibrosis during the course of chemotherapy-induced pneumonitis.
Asia Pac J Clin Oncol
; 16(2): e131-e138, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-31111595
ABSTRACT
BACKGROUND:
The purpose of our study is to evaluate risk factors for the development of pulmonary fibrosis in the baseline computed tomography (CT) during the course of chemotherapy-induced pneumonitis (CIP).METHODS:
We retrospectively identified 80 cases of CIP by clinical, radiological, and pathological findings. When fibrosis developed during the follow-up, the extent of pulmonary fibrosis was evaluated at final follow-up CT in terms of a 5% volumetric score for six zones. Univariate and multivariate analyses were performed to identify the clinical and radiological risk factors for the development of fibrosis and severe fibrosis over 11% in extent.RESULTS:
Fibrosis occurred in 26 of the 80 total patients (32.5%) during a mean 5.6 months of follow up. Risk factors for developing fibrosis were revealed as preexisting interstitial lung disease (ILD) and moderate to severe emphysema in multivariate analysis (OR = 10.12, 95% CI = 2.35-43.66, and OR = 12.85, 95% CI = 2.81-58.82, respectively). Risk factors for developing severe fibrosis over 11% in extent were revealed as a moderate to severe emphysema (OR = 5.78, 95% CI = 1.07-31.26) in multivariate analysis.CONCLUSIONS:
Moderate to severe emphysema as well as preexisting ILD visible on baseline CT are risk factors for developing pulmonary fibrosis in the course of CIP. Thin-section CT may be helpful to predict the risk of pulmonary fibrosis before administering chemotherapy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumonia
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Fibrose Pulmonar
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Tomografia Computadorizada por Raios X
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Quimioterapia de Indução
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article