The prognostic effect of anatomic subsite in HPV-positive oropharyngeal squamous cell carcinoma.
Am J Otolaryngol
; 40(4): 567-572, 2019.
Article
em En
| MEDLINE
| ID: mdl-31113681
ABSTRACT
BACKGROUND:
Since most HPV-associated disease occurs in the tonsillar-related areas (TRA) - palatine and lingual tonsils, the effect of HPV on survival in non-tonsillar oropharyngeal subsites (nTRA) is not well established. The objective of this study was to use a large population-based cohort to investigate the survival impact of HPV in nTRA subsites versus TRA subsites.METHODS:
This SEER database study was conducted by stratifying the HPV-positive oropharyngeal cancer cohort into two primary groups, TRA and nTRA.RESULTS:
HPV-positive squamous cell cancer was significantly more common in TRAs (73%) compared to nTRAs (31.2%, pâ¯<â¯0.001). After controlling for age, treatment, stage, race, and income, patients with HPV-positive disease in nTRAs had a worse cause-specific survival (CSS) than individuals with HPV-positive disease in TRAs (HRâ¯=â¯2.16, 95% CI 1.20-3.86, pâ¯=â¯0.01).CONCLUSION:
Patients with HPV-positive OPSCC in nTRAs had poorer survival outcomes compared to patients with HPV-positive OPSCC in TRAs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
Carcinoma de Células Escamosas
/
Neoplasias Orofaríngeas
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article