CaMKK2 Signaling in Metabolism and Skeletal Disease: a New Axis with Therapeutic Potential.
Curr Osteoporos Rep
; 17(4): 169-177, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31115859
ABSTRACT
PURPOSE OF REVIEW Age and metabolic disorders result in the accumulation of advanced glycation endproducts (AGEs), oxidative stress, and inflammation, which cumulatively cause a decline in skeletal health. Bone becomes increasingly vulnerable to fractures and its regenerative capacity diminishes under such conditions. With a rapidly aging population in the USA and the global increase in diabetes, efficacious, multi-dimensional therapies that can treat or prevent skeletal diseases associated with metabolic dysfunction and inflammatory disorders are acutely needed. RECENT FINDINGS:
Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a key regulator of nutrient intake, glucose metabolism, insulin production, and adipogenesis. Recent studies suggest a pivotal role for CaMKK2 in bone metabolism, fracture healing, and inflammation. Aside from rekindling previous concepts of CaMKK2 as a potent regulator of whole-body energy homeostasis, this review emphasizes CaMKK2 as a potential therapeutic target to treat skeletal diseases that underlie metabolic conditions and inflammation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Ósseas Metabólicas
/
Envelhecimento
/
Consolidação da Fratura
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Diabetes Mellitus Tipo 2
/
Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina
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Inflamação
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Obesidade
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article