Diastereoselective One-Pot Synthesis of Oxazolines Using Sulfur Ylides and Acyl Imines.
J Org Chem
; 84(11): 7219-7226, 2019 06 07.
Article
em En
| MEDLINE
| ID: mdl-31117573
ABSTRACT
This work describes an extended version of the Corey-Chaykovsky reaction to access oxazolines using sulfur ylides and stable precursors of acyl imines. The reaction proceeds through a mixture of aziridines and oxazolines, which provides the trans-oxazolines following in situ Heine-type aziridine ring expansion upon treatment with BF3·OEt2. Following the same one-pot procedure, amidine imides react with the sulfur ylides to provide imidazolines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article