Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells.
J Asian Nat Prod Res
; 22(5): 452-463, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-31119952
ABSTRACT
The effects of coptisine against advanced stage of human pancreatic carcinoma PANC-1 cells was investigated in vitro. Coptisine (25-150 µM) treatment for 48 h caused dose-dependent cell growth inhibition by using CCK-8 assay. Additionally, coptisine was found to inhibit PANC-1 cells metastasis by the wound healing assay. Flow cytometry data indicated that coptisine (25-100 µM) exhibited dose-dependent G1 phase arrest and moderate reduction of S phase. Coptisine was also found to inhibit ERK phosphorylation and total ERK levels. Our research suggested that coptisine would be a potential therapeutic drug for the treatment of pancreatic cancer.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Apoptose
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article