Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
Bioorg Med Chem Lett
; 29(14): 1732-1736, 2019 07 15.
Article
em En
| MEDLINE
| ID: mdl-31126855
ABSTRACT
OSW-1 is a plant-derived natural product proposed to selectively kill cancer cells by binding to members of the oxysterol binding protein family, thereby disrupting lipid/sterol homeostasis. However, how these protein-ligand interactions mediate cell death signaling has remained elusive. Here, we discovered that OSW-1 selectively activates the Golgi stress response leading to apoptosis, providing a mechanistic basis for the anticancer activity of OSW-1.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saponinas
/
Colestenonas
/
Complexo de Golgi
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article