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Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism.
Ballard, Eloise; Weber, Jakob; Melchers, Willem J G; Tammireddy, Seshu; Whitfield, Phillip D; Brakhage, Axel A; Brown, Alistair J P; Verweij, Paul E; Warris, Adilia.
Afiliação
  • Ballard E; MRC Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, UK.
  • Weber J; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.
  • Melchers WJG; Centre for Expertise in Mycology and Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
  • Tammireddy S; Lipidomics Research Facility, Division of Biomedical Sciences, University of the Highlands and Islands, UK.
  • Whitfield PD; Lipidomics Research Facility, Division of Biomedical Sciences, University of the Highlands and Islands, UK.
  • Brakhage AA; Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.
  • Brown AJP; MRC Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, UK.
  • Verweij PE; Centre for Expertise in Mycology and Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
  • Warris A; MRC Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, UK. Electronic address: a.warris@abdn.ac.uk.
Fungal Genet Biol ; 130: 98-106, 2019 09.
Article em En | MEDLINE | ID: mdl-31128273
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergillus fumigatus / Azóis / Polimorfismo de Nucleotídeo Único / Farmacorresistência Fúngica Múltipla / Sistemas CRISPR-Cas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergillus fumigatus / Azóis / Polimorfismo de Nucleotídeo Único / Farmacorresistência Fúngica Múltipla / Sistemas CRISPR-Cas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article