Molecular Docking and Molecular Dynamics (MD) Simulation of Human Anti-Complement Factor H (CFH) Antibody Ab42 and CFH Polypeptide.

Yang, Bing; Lin, Shu-Jian; Ren, Jia-Yi; Liu, Tong; Wang, Yue-Ming; Li, Cheng-Ming; Xu, Wen-Wen; He, You-Wen; Zheng, Wei-Hong; Zhao, Jian; Yuan, Xiao-Hui; Liao, Hua-Xin

Yang, Bing; Lin, Shu-Jian; Ren, Jia-Yi; Liu, Tong; Wang, Yue-Ming; Li, Cheng-Ming; Xu, Wen-Wen; He, You-Wen; Zheng, Wei-Hong; Zhao, Jian; Yuan, Xiao-Hui; Liao, Hua-Xin.

Afiliação

Yang B; Institute of Biomedicine, Jinan University, Guangzhou 510632, China. candyYang_3940@163.com.
Lin SJ; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Guangzhou 510632, China. candyYang_3940@163.com.
Ren JY; Institute of Biomedicine, Jinan University, Guangzhou 510632, China. linshujian18@163.com.
Liu T; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Guangzhou 510632, China. linshujian18@163.com.
Wang YM; Zhuhai College of Jilin University, Zhuhai 519041, China. jiayi80@126.com.
Li CM; Institute of Biomedicine, Jinan University, Guangzhou 510632, China. liutong_smile@163.com.
Xu WW; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Guangzhou 510632, China. liutong_smile@163.com.
He YW; Institute of Biomedicine, Jinan University, Guangzhou 510632, China. ws_wym@126.com.
Zheng WH; National Engineering Research Center of Genetic Medicine, Guangzhou 510632, China. ws_wym@126.com.
Zhao J; Institute of Biomedicine, Jinan University, Guangzhou 510632, China. cli816@163.com.
Yuan XH; National Engineering Research Center of Genetic Medicine, Guangzhou 510632, China. cli816@163.com.
Liao HX; Institute of Biomedicine, Jinan University, Guangzhou 510632, China. xuwenwen@jnu.edu.cn.

Int J Mol Sci ; 20(10)2019 May 25.

Article em En | MEDLINE | ID: mdl-31130605

Assuntos

Anticorpos Monoclonais/imunologia; Peptídeos/imunologia; Anticorpos Monoclonais/química; Reações Antígeno-Anticorpo; Autoanticorpos/química; Autoanticorpos/imunologia; Fator H do Complemento/química; Fator H do Complemento/imunologia; Regiões Determinantes de Complementaridade/química; Regiões Determinantes de Complementaridade/imunologia; Epitopos/química; Epitopos/imunologia; Humanos; Simulação de Acoplamento Molecular; Simulação de Dinâmica Molecular; Neoplasias/imunologia; Peptídeos/química; Conformação Proteica

Palavras-chave

complement factor H (CFH); complementarity-determining region (CDR); computational alanine scanning (CAS); experimental alanine scanning (EAS); molecular docking; molecular dynamics (MD) simulation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Anticorpos Monoclonais Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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