BLK and BANK1 polymorphisms and interactions are associated in Mexican patients with systemic lupus erythematosus.
Inflamm Res
; 68(8): 705-713, 2019 Aug.
Article
em En
| MEDLINE
| ID: mdl-31134304
ABSTRACT
OBJECTIVES:
The BLK and BANK1 genes have been consistently associated with systemic lupus erythematosus (SLE), primarily in European or Asian-derived populations. However, this finding has not been replicated in Latin-American patients.METHODS:
Our study included 881 women from Mexico 487 healthy controls and 394 SLE patients. The BLK rs13277113A/G-rs2736340T/C as well as BANK1 rs10516487G/A (R61H)-rs3733197G/A (A383T) single nucleotide polymorphisms (SNPs) were evaluated using a TaqMan® SNP genotyping assay.RESULTS:
Our data showed that the BLK rs2736340T/C and rs13277113A/G polymorphisms are associated with susceptibility to SLE (C vs T, OR 1.60, p = 2×10-5; G vs A, OR 1.53, p = 9 × 10-5, respectively). We also identified an association between the functional BANK1 R61H polymorphism and SLE (A vs G, OR 1.56, p = 0.002). In addition, we observed a genetic interaction between BLK (rs2736340T/C, rs13277113A/G) and BANK1 (R61H and A383T) associated with susceptibility to SLE.CONCLUSION:
This is the first study documenting an association between BLK and BANK1 and SLE in a Latin-American population. Our data confirm previous reports BLK and BANK1 are factors associated with SLE. Thus, both genes are universal loci for this autoimmune disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinases da Família src
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Proteínas Adaptadoras de Transdução de Sinal
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Lúpus Eritematoso Sistêmico
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Proteínas de Membrana
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Middle aged
País/Região como assunto:
Mexico
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article