Physicochemical stability of oxycodone-ketamine solutions in polypropylene syringe and polyvinyl chloride bag for patient-controlled analgesia use.
Eur J Hosp Pharm
; 25(4): 214-217, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-31157023
ABSTRACT
OBJECTIVES:
The study evaluated the stability of three combinations of oxycodone and ketamine diluted in normal saline (NS) after storage for 7â days at 23°C and exposed to light.METHODS:
The stability of three mixtures of oxycodone and ketamine (oxycodone 0.4â mg/mL+ketamine 40â mg/mL, oxycodone 10â mg/mL+ketamine 0.1â mg/mL and oxycodone 10â mg/mL+ketamine 40â mg/mL) in NS stored in a polypropylene syringe and a polyvinyl chloride (PVC) bag was studied. The physical characteristics, including pH, colour and precipitation, were evaluated. The samples were analysed in triplicate by a stability-indicating high-performance liquid chromatography method.RESULTS:
There was no significant change in the pH values of any solution. No precipitation or change in colour was observed. All formulations maintained more than 95% of the initial concentration of each drug on day 7. No trace of degradation products was detected.CONCLUSIONS:
Ketamine (0.1-40â mg/mL) combined with oxycodone (0.4-10â mg/mL) is physically compatible and chemically stable for 7â days when diluted with NS, packaged in polypropylene syringe or PVC bag and stored at 23°C.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article