Your browser doesn't support javascript.
loading
Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models.
Le, Hoan N; Tran, Vuvi G; Vu, Trang T T; Gras, Emmanuelle; Le, Vien T M; Pinheiro, Marcos Gabriel; Aguiar-Alves, Fábio; Schneider-Smith, Erika; Carter, Henry Clay; Sellman, Bret R; Stover, C Kendall; DiGiandomenico, Antonio; Diep, Binh An.
Afiliação
  • Le HN; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Tran VG; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Vu TTT; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Gras E; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Le VTM; François Rabelais University, Tours, France.
  • Pinheiro MG; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Aguiar-Alves F; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Schneider-Smith E; Pathology Program, Fluminense Federal University, Rio de Janeiro, Brazil.
  • Carter HC; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Sellman BR; Pathology Program, Fluminense Federal University, Rio de Janeiro, Brazil.
  • Stover CK; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • DiGiandomenico A; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Diep BA; Microbial Sciences, AstraZeneca, Gaithersburg, Maryland, USA.
Antimicrob Agents Chemother ; 63(8)2019 08.
Article em En | MEDLINE | ID: mdl-31160288
ABSTRACT
Pseudomonas aeruginosa is a challenge for clinicians due to increasing drug resistance and dwindling treatment options. We report on the activity of MEDI3902, an antibody targeting type 3 secretion protein PcrV and Psl exopolysaccharide, in rabbit bloodstream and lung infection models. MEDI3902 prophylaxis or treatment was protective in both acute models and exhibited enhanced activity when combined with a subtherapeutic dose of meropenem. These findings further support MEDI3902 for the prevention or treatment of serious P. aeruginosa infections.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Pseudomonas aeruginosa / Infecções por Pseudomonas / Anticorpos Biespecíficos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Pseudomonas aeruginosa / Infecções por Pseudomonas / Anticorpos Biespecíficos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article