COMBImage2: a parallel computational framework for higher-order drug combination analysis that includes automated plate design, matched filter based object counting and temporal data mining.

Chantzi, Efthymia; Jarvius, Malin; Niklasson, Mia; Segerman, Anna; Gustafsson, Mats G

Chantzi, Efthymia; Jarvius, Malin; Niklasson, Mia; Segerman, Anna; Gustafsson, Mats G.

Afiliação

Chantzi E; Department of Medical Sciences, Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden. efthymia.chantzi@medsci.uu.se.
Jarvius M; Department of Medical Sciences, Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden.
Niklasson M; SciLifeLab Drug Discovery and Development, In Vitro Systems Pharmacology Facility, Uppsala University, Uppsala, Sweden.
Segerman A; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Gustafsson MG; Department of Medical Sciences, Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden.

BMC Bioinformatics ; 20(1): 304, 2019 Jun 04.

Article em En | MEDLINE | ID: mdl-31164078

Assuntos

Antineoplásicos/uso terapêutico; Mineração de Dados/métodos; Combinação de Medicamentos; Glioblastoma/tratamento farmacológico; Algoritmos; Apoptose; Humanos; Microscopia de Vídeo; Recidiva Local de Neoplasia/tratamento farmacológico; Projetos Piloto

Palavras-chave

Automated plate design; CUSP9v4; Data mining; Glioblastoma; Higher-order drug combination analysis; Label-free time-lapse video microscopy; MapReduce; Matched filter; Resampling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glioblastoma / Combinação de Medicamentos / Mineração de Dados / Antineoplásicos Tipo de estudo: Guideline Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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