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A Nutrition-Longevity Tradeoff Enforced by Innate Immunity.
Wani, Khursheed A; Goswamy, Debanjan; Irazoqui, Javier E.
Afiliação
  • Wani KA; Department of Microbiology and Physiological Systems and Program in Innate Immunity, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Goswamy D; Department of Microbiology and Physiological Systems and Program in Innate Immunity, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Irazoqui JE; Department of Microbiology and Physiological Systems and Program in Innate Immunity, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: javier.irazoqui@umassmed.edu.
Mol Cell ; 74(5): 864-865, 2019 06 06.
Article em En | MEDLINE | ID: mdl-31173721
ABSTRACT
Dietary restriction (DR) extends lifespan in multiple animal species, but the underlying molecular mechanisms remain poorly understood. A recent study published in Cell Metabolism by Wu et al. (2019) shows that DR represses an evolutionarily conserved p38 MAPK pathway involved in innate immunity, leading to diminished expression of p38 MAPK-regulated genes and extended lifespan.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunidade Inata / Longevidade Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunidade Inata / Longevidade Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article