Genetic diversity of HLA system in a population sample from Aguascalientes, Mexico.
Hum Immunol
; 81(9): 519-521, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-31174911
ABSTRACT
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 95 Mexicans from the state of Aguascalientes to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes in the state of Aguascalientes include four Native American, three European and one Asian haplotypes. Admixture estimates revealed that the main genetic components in the state of Aguascalientes are Native American (54.53⯱â¯3.22% by ML; 44.21% of Native American haplotypes) and European (44.34⯱â¯0.45% by ML; 40.53% of European haplotypes), and a relatively low African genetic component (1.13⯱â¯2.33% by ML; 5.26% of African haplotypes).
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Genética Populacional
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Antígenos HLA
Limite:
Humans
País/Região como assunto:
Mexico
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article