Tau local structure shields an amyloid-forming motif and controls aggregation propensity.

Chen, Dailu; Drombosky, Kenneth W; Hou, Zhiqiang; Sari, Levent; Kashmer, Omar M; Ryder, Bryan D; Perez, Valerie A; Woodard, DaNae R; Lin, Milo M; Diamond, Marc I; Joachimiak, Lukasz A

Tau local structure shields an amyloid-forming motif and controls aggregation propensity.

Chen, Dailu; Drombosky, Kenneth W; Hou, Zhiqiang; Sari, Levent; Kashmer, Omar M; Ryder, Bryan D; Perez, Valerie A; Woodard, DaNae R; Lin, Milo M; Diamond, Marc I; Joachimiak, Lukasz A.

Afiliação

Chen D; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Drombosky KW; Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Hou Z; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Sari L; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Kashmer OM; Green Center for Molecular, Computational and Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Ryder BD; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Perez VA; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Woodard DR; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Lin MM; Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Diamond MI; Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Joachimiak LA; Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Nat Commun ; 10(1): 2493, 2019 06 07.

Article em En | MEDLINE | ID: mdl-31175300

Assuntos

Agregação Patológica de Proteínas/genética; Tauopatias/genética; Proteínas tau/genética; Motivos de Aminoácidos/genética; Simulação por Computador; Células HEK293; Humanos; Espectrometria de Massas; Microscopia Eletrônica de Transmissão; Mutação de Sentido Incorreto; Agregação Patológica de Proteínas/metabolismo; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Proteínas Recombinantes/ultraestrutura; Proteínas tau/metabolismo; Proteínas tau/ultraestrutura

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas tau / Tauopatias / Agregação Patológica de Proteínas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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