Synthesis of modified 1,5-imino-d-xylitols as ligands for lysosomal ß-glucocerebrosidase.
Monatsh Chem
; 150(5): 831-842, 2019.
Article
em En
| MEDLINE
| ID: mdl-31178604
ABSTRACT
ABSTRACT Modified 1,5-dideoxy-1,5-imino-d-xylitol analogues with different substitution patterns involving position C-1 and/or the ring nitrogen were prepared, which were designed to serve as precursors for the preparation of iminoxylitol-based ligands and tools for the elucidation and modulation of human lysosomal ß-glucocerebrosidase. Biological evaluation of the synthesized glycomimetics with a series of glycoside hydrolases revealed that these substitution patterns elicit excellent ß-glucosidase selectivities.
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Coleções:
01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article