Common Biological Mechanisms of Alcohol Use Disorder and Post-Traumatic Stress Disorder.
Alcohol Res
; 39(2): 131-145, 2018.
Article
em En
| MEDLINE
| ID: mdl-31198653
ABSTRACT
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid. Although recent clinical studies provide some understanding of biological and subsequent behavioral changes that define each of these disorders, the neurobiological basis of interactions between PTSD and AUD has not been well-understood. In this review, we summarize the relevant animal models that parallel the human conditions, as well as the clinical findings in these disorders, to delineate key gaps in our knowledge and to provide potential clinical strategies for alleviating the comorbid conditions.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Hipófise-Suprarrenal
/
Transtornos de Estresse Pós-Traumáticos
/
Encéfalo
/
Modelos Animais de Doenças
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Alcoolismo
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Sistema Hipotálamo-Hipofisário
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article