Schizophrenia as a pseudogenetic disease: A call for more gene-environmental studies.
Psychiatry Res
; 278: 146-150, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31200193
ABSTRACT
In recent years schizophrenia has been assumed to be largely a genetic disease with heritability estimates, derived primarily from family and twin studies, of 80%-85%. However, the results of genetic research on schizophrenia have not yielded results consistent with that estimate of heritability. In particular, extensive genetic studies have not led to new methods for diagnosis and treatment. An examination of the twin studies on which heritability is based shows why such studies exaggerate the genetic component of schizophrenia. In addition, the effects of infectious agents such as Toxoplasma gondii and the composition of the microbiome can produce a clinical picture that would also appear to be largely genetic due to familial aggregation and a role for a partial genetic contribution to the immune system. It is concluded that the genetic component of schizophrenia may have been overestimated and an increased focus on gene-environmental interactions is likely to accelerate research progress on this disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Estudos em Gêmeos como Assunto
/
Suscetibilidade a Doenças
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Interação Gene-Ambiente
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article